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Insights in Stem Cells

About Insights in Stem Cells

Insights in Stem Cells is an international open access, peer-reviewed academic journal. The journal is dedicated to publish quality articles with an emphasis on basic, translational and clinical research on stem cell. The journal is a broad forum focusing on the studies of biology and applications of stem cell including animal models and clinical trials. Authors are invited to contribute articles in the form of original research, review articles, critical analysis, scientific investigation reports, case reports, technical notes, letter to the editor, and commentaries on scientific, ethical, social and economic importance with relation to stem cell research.

Insights in stem cell  publishes articles that cover all aspects of Stem cell therapy, Stem cell transplant, Stem cell biology, Cancer stem cell, Therapeutic cloning, Neural stem cells, Somatic  stem cell, regenerative medicine.

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Pluripotent Cells

Pluripotent stem cells are often termed true stem cells because they have the potential to differentiate into almost any cell in the body. Pluripotent, embryonic stem cells originate as inner mass cells within a blastocyst. These stem cells can become any tissue in the body, excluding a placenta. They have the potential to develop into any type of human cell.

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Insights in Stem CellsHealth Systems and Policy ResearchJournal of Fertilization: In Vitro - IVF-Worldwide, Reproductive Medicine, Genetics & Stem Cell Biology,Bioenergetics: Open AccessAnatomy & Physiology: Current Research, Journal of Hematotherapy and Stem  Cell  Research, Journal of Stem  Cell and Regenerative Medicine, Stem Cells and Cloning: Advances and Applications.

Fetal Stem Cells

Cells derived from a Fetus that retains the ability to divide, proliferate and provide progenitor cells that can differentiate into specialized cells. The embryo is referred to as a fetus after the eighth week of development. Once a fetal stem cell has been harvested, it has the potential to live indefinitely in the laboratory. Fetal stem cells can be isolated from fetal blood and bone marrow as well as from other fetal tissues, including liver and kidney.

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Stem Cell Technologies

Stem cell technology is a rapidly developing field that combines the efforts of cell biologists, geneticists, and clinicians and offers hope of effective treatment for a variety of malignant and non-malignant diseases. The ability of tissue stem cells to integrate into the tissue cytoarchitecture under the control of the host microenvironment and developmental cues makes them ideal for cell replacement therapy.

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Embryonic Stem Cells

Embryonic stem cells are derived from totipotent cells of the early mammalian embryo and are capable of unlimited, undifferentiated proliferation in vitro. It is known as a blastocyst and has two parts i.e., trophectoderm and inner cell mass. Embryonic stem cell's properties include having a normal karyotype, maintaining high telomerase activity, and exhibiting remarkable long-term proliferative potential. Human ES cells measure approximately 14 μm

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Cancer Stem Cells

Cancer stem cells are a subset of cancer cells which play a key role in predicting the biological aggressiveness of cancer due to its ability of self-renewal and multi-lineage differentiation. CSCs are potentially of profound clinical importance. They establish the clinical relevance of breast CSC markers by profiling a large cohort of breast tumours in tissue microarrays using Immunohistochemistry.

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Bone Marrow Stem Cells

Bone marrow is the soft, sponge-like material found inside bones. It contains immature cells known as hematopoietic or blood-forming stem cells. Bone marrow transplantation is a procedure that restores stem cells that have been destroyed by high doses of chemotherapy and/or radiation therapy. Bone marrow or stem cell transplants are used to treat some types of leukaemia or lymphoma, and myeloma.

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Endothelial Cells

The endothelium is the thin layer of simple squamous cells that lines the interior surface of blood vessels and lymphatic vessels, cells that form the endothelium are called endothelial cells. The main function of endothelial cells is to provide a barrier between the blood and the rest of the body tissues. The endothelial cells act like a sieve, restricting the passage of large molecules, toxic substances and bacteria into the brain tissue while allowing necessary molecules like oxygen, enzymes and hormones.

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Stem Cells: Controversies & Regulation

The stem cell controversy is the consideration of the ethics of research involving the development, usage, and destruction of human embryos. The controversy centered on the moral implications of destroying human embryos. Many funding and research restrictions on embryonic cell research will not impact research on induced pluripotent stem cells allowing for a promising portion of the field of research to continue relatively unhindered by the ethical issues of embryonic research.

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Hair Stem Cell

Hair follicles also contain stem cells, and some researchers predict research on these follicle stem cells may lead to successes in treating baldness through an activation of the stem cells progenitor cells. Stem-cell therapy led to a significant and visible improvement in follicular hair growth. New hair grew effectively using human pluripotent stem cells, cells derived from human embryos or human fetal tissue that can become any other cell type in the body.

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Stem Cell Therapy

Stem cell therapy is the use of stem cells to treat or prevent a disease or condition. Bone marrow transplant is the most widely used stem cell therapy. Bone-marrow has been used to treat cancer patients with conditions such as leukaemia and lymphoma. Stem cell treatment protocols employ well-targeted combinations of allogeneic human umbilical cord stem cells, autologous bone marrow stem cells, and autologous adipose stem cells, and to treat the diseases.

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Stem-Cell Transplantation

Stem cell transplantation is the transplantation of multipotent stem cells, usually derived from bone marrow, peripheral blood, or umbilical cord blood. The two main types of stem cell transplants are autologous and allogeneic. It is a medical procedure in the field of hematology, most often performed for patients with certain cancers of the blood or bone marrow, such as multiple myeloma or leukemia.

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Regenerative Medicine

Regenerative medicine is a branch of translational research in tissue engineering and molecular biology which deals with the process of replacing, engineering or regenerating human cells, tissues or organs to restore or establish normal function. Regenerative medicine also includes the possibility of growing tissues and organs in the laboratory and safely implanting them when the body cannot heal itself. Examples include the injection of stem cells or progenitor cells obtained through Directed differentiation.

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Human Embryonic Stem Cells

Human embryonic stem cell are also known as a human pluripotent stem cell, one of the cells that are self-replicating, are derived from human embryos or human fetal tissue, and are known to develop into cells and tissues of the three primary germ layers. Human embryonic stem cell research is thought to have great potential in disorders in which cellular loss is known to occur.

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Neural stem cells

Neural stem cells are stem cells in the nervous system that can self-renew and give rise to differentiated progenitor cells to generate lineages of neurons as well as glia, such as astrocytes and oligodendrocytes. These cells hold great promise for neural repair after injury or disease. The potential source of neural stem cells for neural repair is through the mobilization of endogenous stem cells.

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Adult Stem Cells

Adult stem cells are undifferentiated cells found throughout the body that divide to replenish dying cells and regenerate damaged tissues. An adult stem cell is an unspecialised cell that is capable of Long term renewal and Differentiation into specialised cell types. The primary function of adult (somatic) stem cells is to maintain tissue homeostasis by replenishing senescent or damaged cells. They are also known as somatic stem cells, they can be found in children, as well as adults.

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Pancreatic Stem Cells

The endocrine pancreas represents an interesting arena for regenerative medicine and cell therapeutics. One of the major pancreatic diseases, diabetes mellitus is a metabolic disorder caused by having an insufficient number of insulin-producing β cells. Replenishment of β cells by cell transplantation can restore normal metabolic control.

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Murine Embryonic Stem Cells

Molecular regulation of embryonic stem cell fate involves a coordinated interaction between epigenetic transcriptional and translational mechanisms. It is unclear how these different molecular regulatory mechanisms interact to regulate changes in stem cell fate. A dynamic systems-level study of cell fate change in murine ESCs following a well-defined perturbation.

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