Abstract

Human pluripotent stem cells (hPSCs) offer numerous functional solutions, but several underlying biological mechanisms, such as epigenetic modifications, still remain to be explored. Recently, there has been an increasing interest in employing whole-genome techniques to profile DNA methylation (DNAm) changes of hPSCs. The results from these studies will increase the knowledge on the molecular mechanisms that underpin hPSCs and their potential use in several fields including disease modelling, drug screening and regenerative medicine.